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34

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72281	Caspase-9 Inhibitor III Ac-LEHD-cmk
	Caspase-9 Inhibitor III (Ac-LEHD-cmk) 是一种 caspase-9抑制剂。Caspase-9 Inhibitor III 对局部缺血-重新灌注诱导的心肌损伤表现出保护作用。
T16104	ML-9	Myosin; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	ML-9 是 Akt 激酶的一种选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。
T22119	NS3694	Apoptosis	Apoptosis
	NS3694 是一种凋亡抑制剂，可抑制凋亡小体形成和半胱天冬酶活化。
T1724	SCR7 pyrazine SCR7,SCR7 吡嗪	Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SCR7 pyrazine (SCR7) 是一种 DNA 连接酶 IV 抑制剂，以连接酶 IV 依赖的方式阻断非同源末端连接。它也是 CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡，具有抗癌活性。
T28178	NLRP3-IN-9 INF-4E,INF 4E,INF4E	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。
TQ0146L	Ac-DEVD-CHO acetate Caspase-3 Inhibitor I,N-acetyl-asp-glu-val-asp-al,Ac-DEVD-CHO acetate (169332-60-9 free base),乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) 是 Caspase-3 的特异性抑制剂。
T3340	SCR7	Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SCR7 是一种特异性 DNA 连接酶 IV 抑制剂，可阻断非同源末端连接。它是一种不稳定的形式，可以自动循环成稳定形式的 SCR7 pyrazine。它也是CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡并具有抗癌活性。
T10366L	Arg-Gly-Asp-Ser acetate Arg-Gly-Asp-Ser acetate(91037-65-9 free base)	Integrin	Cytoskeletal Signaling
	Arg-Gly-Asp-Ser acetate 是一种整合素结合序列，可直接特异性结合 pro-caspase-8、pro-caspase-9 和 pro-caspase-3，但不结合 pro-caspase-1。它抑制整合素受体功能。
T21835	Z-LEHD-fmk	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Z-LEHD-FMK 是一种具有选择性和有效性的 caspase-9 抑制剂，可防减轻再灌注损伤，减缓细胞凋亡。Z-LEHD-FMK 具有抗肿瘤和神经保护活性，可提高体外生产的水牛（Bubalus bubalis）植入前胚胎的产量并改变细胞应激反应。
T14298	Rimiducid	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Rimiducid 是一种可渗透脂质的他克莫司类似物，是一种二聚剂，通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。
T9083	TC11 CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11	BCL; Caspase; CDK	Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome
	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂，并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间，它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。
T1933	NVP 231	Apoptosis; ERK	Apoptosis; MAPK
	NVP 231 是一种强效、特异、可逆的神经酰胺激酶抑制剂，IC50值为12 nM，可竞争性地抑制神经酰胺与 CerK 的结合。它通过增加 DNA 片段和 caspase-3 和 caspase-9 的裂解来诱导细胞凋亡。
T27242	EF24 EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone	ERK; MEK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) 是姜黄素类似物，口服生物利用度高，抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平，并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路，从而发挥抗肿瘤作用。
T1266	Terfenadine (±)-Terfenadine,特非那定,MDL-991	Apoptosis; Potassium Channel; 5-HT Receptor; Caspase; Na+/Ca2+ Exchanger; HER; AChR; Histamine Receptor	Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Terfenadine ((±)-Terfenadine) 是一种hERG 开放通道抑制剂，IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂，通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡，同时激活Caspase-4，-2，-9。
T0282	Q-VD-OPH Quinoline-Val-Asp-Difluorophenoxymethylketone	Caspase; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) 是一种具有强效抗凋亡特性的泛半胱天冬酶抑制剂。它可抑制 HIV 感染，能透过血脑屏障。
T21293	MX1013 MX 1013,MX-1013
	MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.
T36342	Ac-LEHD-AMC (trifluoroacetate salt)
	Ac-LEHD-AMC is a fluorogenic substrate for caspase-9.[1] Upon cleavage by caspase-9, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-9 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T73870	Arg-Gly-Asp-Ser TFA
	Arg-Gly-Asp-Ser (TFA) 为整联蛋白结合序列，专门抑制整联蛋白受体(integrin receptor)功能。它能够直接且特异性地与pro-caspase-8、pro-caspase-9和pro-caspase-3结合，而不与pro-caspase-1发生作用。
T71839	ATV399
	ATV399 is an inhibitor of iNOS dimerization which protects against Cytokine-Induced rat β-cell dysfunction, thereby inhibiting cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ, and high glucose.
T80537	Ac-AAVALLPAVLLALLAP-LEHD-CHO	Caspase	Apoptosis; Proteases/Proteasome
	Ac-AAVALLPAVLLALLAP-LEHD-CHO 是半胱天冬酶4、5和9的抑制剂，能够对Neocarzinostatin处理的MCF-7细胞展现保护效果。
T40602	Z-LEHD-FMK TFA
	Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, offering protection against detrimental reperfusion injury and moderating apoptosis. Additionally, Z-LEHD-FMK TFA demonstrates its neuroprotective potential in a rat model of spinal cord trauma.
T25032	ALC67 ALC-67,ALC 67
	ALC67 has a promising anticancer activity that results in the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. It is an activator of the caspase-9 involved apoptotic pat
T36190	CAY10443 CAY10443
	Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 μM. These apoptotic activators represent therapeutic lead compounds for the developme...
T70527	DAT-230
	DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated ...
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T69323	Dexamethasone sodium succinate
	Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regul...
T78873	CTL-12
	CTL-12是一种Fatty Acid Synthase (FASN)抑制剂（IC50: 2.5 μM），能够诱导apoptosis。它使细胞周期在Sub-G1/S期停滞并增加caspase-9和凋亡标志物Bax的表达，同时减少抗凋亡标志物Bcl-xL的水平。CTL-12通过抑制de novo脂肪酸合成，切断了肿瘤细胞的代谢需求，是乳腺癌和结直肠癌研究中的重要工具。
T74783	HDAC-IN-53	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-53是一种口服活性的选择性HDAC1-3抑制剂，其IC50分别为47 nM、125 nM和450 nM。该化合物不针对II类HDAC(HDAC4、5、6、7、9；IC50>10 μM)展现抑制作用。HDAC-IN-53能够诱导caspase依赖的细胞凋亡并在裸鼠中显著抑制人肿瘤异种移植物生长，同时抑制携带MC38结肠癌的免疫活性小鼠的肿瘤发展。
T36201	AZD5582 dihydrochloride AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP...
T78872	CTL-06
	CTL-06是一种Fatty Acid Synthase (FASN)抑制剂，具有3 μM的IC50，能够诱发细胞凋亡。CTL-12导致细胞周期在Sub-G1/S期停滞，并增加caspase-9和凋亡标志物Bax的表达，减少抗凋亡标志物Bcl-xL的表达。此外，CTL-12通过抑制脂肪酸的从头合成，剥夺肿瘤细胞代谢所需，主要用于乳腺癌和结直肠癌的研究。
T72475	Anticancer agent 58
	Anticancer agent 58 对多种癌细胞具有抑制活性，特别是在 A549 和 T24 细胞中，IC50分别为 0.6 μM 和 0.7 μM。Anticancer agent 58 通过激活 caspase3/8/9活性诱导细胞凋亡 (apoptosis)，也诱导 Ca2+和 ROS 水平升高。Anticancer agent 58 在 T24 异种移植小鼠模型中能显著抑制肿瘤生长。
T28092	MPT0B206
	MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2.
T71217	MPT0B214
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of th...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

Caspase-9 Inhibitor III

Cat.No: T72281

Synonym: Ac-LEHD-cmk

Cat.No: T16104

Target: Myosin, Akt

Cat.No: T22119

Target: Apoptosis

Cat.No: T1724

Synonym: SCR7,SCR7 吡嗪

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Cat.No: T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Ac-DEVD-CHO acetate

Cat.No: TQ0146L

Synonym: Caspase-3 Inhibitor I,N-acetyl-asp-glu-val-asp-al,Ac-DEVD-CHO acetate (169332-60-9 free base),乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛

Target: Caspase

Cat.No: T3340

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Arg-Gly-Asp-Ser acetate

Cat.No: T10366L

Synonym: Arg-Gly-Asp-Ser acetate(91037-65-9 free base)

Target: Integrin

Cat.No: T21835

Target: Apoptosis, Caspase

Cat.No: T14298

Target: Apoptosis, Others, Fatty Acid Synthase

Cat.No: T9083

Synonym: CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

Target: BCL, Caspase, CDK

Cat.No: T1933

Target: Apoptosis, ERK

Cat.No: T27242

Synonym: EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

Target: ERK, MEK, Caspase

Cat.No: T1266

Synonym: (±)-Terfenadine,特非那定,MDL-991

Target: Apoptosis, Potassium Channel, 5-HT Receptor, Caspase, Na+/Ca2+ Exchanger, HER, AChR, Histamine Receptor

Cat.No: T0282

Synonym: Quinoline-Val-Asp-Difluorophenoxymethylketone

Target: Caspase, HIV Protease

Cat.No: T21293

Synonym: MX 1013,MX-1013

Ac-LEHD-AMC (trifluoroacetate salt)

Cat.No: T36342

Arg-Gly-Asp-Ser TFA

Cat.No: T73870

Cat.No: T71839

Ac-AAVALLPAVLLALLAP-LEHD-CHO

Cat.No: T80537

Target: Caspase

Cat.No: T40602

Cat.No: T25032

Synonym: ALC-67,ALC 67

Cat.No: T36190

Synonym: CAY10443

Cat.No: T70527

Cat.No: T69200

Dexamethasone sodium succinate

Cat.No: T69323

Cat.No: T78873

Cat.No: T74783

Target: HDAC

AZD5582 dihydrochloride

Cat.No: T36201

Synonym: AZD 5582 dihydrochloride

Cat.No: T78872

Anticancer agent 58

Cat.No: T72475

Cat.No: T28092

Cat.No: T71217

Cat.No: T37861

Cat. No.	Product Name	Target	Signaling Pathways
T2S0410	Euphorbia factor L1 Euphorbiasteroid,大戟因子L1,大戟因子 L1	Apoptosis; P-gp	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2，PI3K，AKT 和 mTOR 蛋白和 mRNA 水平，上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬，具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。
T5S2083	Puerarin 6''-O-Xyloside	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Puerarin 6''-O-Xyloside 是从葛根中分离得到的一种天然产物，可诱导线粒体介导的细胞凋亡通路，有抗炎和抗癌活性。
TN1880	Lucidenic acid B Lucidenicacid B	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物，可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解，可通过线粒体介导诱导人白血病细胞凋亡。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。
T2959	Ginsenoside Rh2 20(S)-Rh2,20S-Ginsenoside Rh2,人参皂苷Rh2,20(S)-Ginsenoside Rh2,人参皂苷 Rh2	Apoptosis; EGFR; Caspase; Endogenous Metabolite	Angiogenesis; Apoptosis; JAK/STAT signaling; Metabolism; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) 诱导caspase-8和caspase-9活化。它以多途径方式诱导癌细胞凋亡。
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
T7452	2-methoxycinnamaldehyde 2'-甲氧基肉桂醛,O-methoxycinnamaldehyde	Apoptosis; Others	Apoptosis; Others
	2-methoxycinnamaldehyde 是一种肉桂中的天然产物。它能通过使线粒体膜电位 (ΔΨm) 损失、激活 caspase-3 和 caspase-9，来抑制细胞增殖和诱导细胞凋亡，具有抗肿瘤活性。它还能抑制血小板衍生生长因子诱导的 HASMC 迁移。
T2909	Fraxetin 7,8-dihydroxy-6-methoxy coumarin,秦皮素,弗拉西汀	Apoptosis; Others	Apoptosis; Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) 是从秦皮中分离出来的一种天然产物，可诱导细胞凋亡，具有抗肿瘤、抗氧化作用和抗炎作用。
TN2103	PROCYANIDIN C1 原花青素 C1,原花青素C1	Apoptosis	Apoptosis
	Procyanidin C1 是一种天然多酚，可造成 DNA 损伤，细胞周期停滞，诱导凋亡。它降低癌细胞中 Bcl-2 的蛋白水平，增强 BAX，caspase 3 和 9 的表达。
T6485	Embelin NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid	Apoptosis; NF-κB; Lipoxygenase; IAP; Prostaglandin Receptor; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB
	Embelin (Embelic acid) 是从日本 Ardisia 草药中分离出来的一种非肽类细胞渗透性XIAP 抑制剂，诱导口腔鳞癌细胞自噬和凋亡。它阻断 NF-kappaB 信号通路，从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。在高水平 XIAP 的前列腺癌细胞中抑制细胞生长，诱导凋亡，并激活 caspase-9。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
TN4087	Furowanin A	Caspase	Apoptosis; Proteases/Proteasome
	Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.
T13956	Uvarigrin	Others	Others
	Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.
T75632	Ganoderic acid T1
	Ganoderic acid T1是Ganoderic acid T的去乙酰化衍生物，具有促进癌细胞凋亡(apoptosis)的功能。它通过降低线粒体膜电位以及激活caspase-9和caspase-3来引发细胞凋亡，并增加细胞内ROS的产生，从而表现出促氧化活性和细胞性毒作用，同时减弱抗氧化防御系统。
TN5456	Isoerysenegalensein E
	Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas
T73403	Aviculin
	Aviculin 是一种木聚糖苷，是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下，IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。
TN2191	Scutebarbatine A	BCL; Caspase	Apoptosis; Proteases/Proteasome
	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 μM, respectively.
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se
TN4046	Excisanin A	MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Euphorbia factor L1

Cat.No: T2S0410

Synonym: Euphorbiasteroid,大戟因子L1,大戟因子 L1

Target: Apoptosis, P-gp

Puerarin 6''-O-Xyloside

Cat.No: T5S2083

Target: Apoptosis, Caspase

Lucidenic acid B

Cat.No: TN1880

Synonym: Lucidenicacid B

Target: Apoptosis, Caspase

Ginsenoside Rh2

Cat.No: T2959

Synonym: 20(S)-Rh2,20S-Ginsenoside Rh2,人参皂苷Rh2,20(S)-Ginsenoside Rh2,人参皂苷 Rh2

Target: Apoptosis, EGFR, Caspase, Endogenous Metabolite

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

2-methoxycinnamaldehyde

Cat.No: T7452

Synonym: 2'-甲氧基肉桂醛,O-methoxycinnamaldehyde

Target: Apoptosis, Others

Cat.No: T2909

Synonym: 7,8-dihydroxy-6-methoxy coumarin,秦皮素,弗拉西汀

Target: Apoptosis, Others

Cat.No: TN2103

Synonym: 原花青素 C1,原花青素C1

Target: Apoptosis

Cat.No: T6485

Synonym: NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid

Target: Apoptosis, NF-κB, Lipoxygenase, IAP, Prostaglandin Receptor, Autophagy

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Cat.No: TN4087

Target: Caspase

Cat.No: T13956

Target: Others

Ganoderic acid T1

Cat.No: T75632

Isoerysenegalensein E

Cat.No: TN5456

Cat.No: T73403

Scutebarbatine A

Cat.No: TN2191

Target: BCL, Caspase

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

Cat.No: TN4046

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

Cat.No: T36954

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